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Painkillers are the measurement of the physical condition of the game's protagonist in Manhunt 2. Its default maximum is 100%.

Painkillers pickups scattered around Cottonmouth can restore the player's health to the maximum level. Painkiller pickups are generally shaped as a small, glass bottle with a lid and a cross logo on it.

Many things can damage the player's health:

  • Being shot
  • Stabbed
  • Being Beaten
  • Exposed to Fire
  • Explosives
  • Falling from heights
  • Hit by a corpse (if Danny punches the White Rabbit corpse in the TVMK Studio, it will swing up and hit him back)
  • Brain being wiped clean

When the player's health is completely depleted, the current level will be failed.

Painkillers can be found in various places, such as:

  • Cabins
  • Trunks
  • Wardrobes
  • Lockers
  • Drawers
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